Area of interest:

Molecular characterization of genetic variants involved in monogenic and complex genetic traits as part of the SardiNIA project. Extension of the classic GWAS method and application of “Whole Genome Sequencing-Based GWAS” by integrating data obtained from genotyping and sequencing through the use of isolated populations in the dissection of multifactorial traits. Validation of bi-allelic polymorphisms. Study of autoimmunity through understanding the role of the genetic and environmental component and elucidation of the responsible mechanisms through genetic characterization. Rational approach for the search for compounds for the treatment of multiple sclerosis based on the analysis of biological targets identified by genome-wide association studies in Sardinia